Allergenic reactions by invading atopic pathogens, well beyond the scope of microbiota, can become initial factors triggering chronic atopic disease.
2.
Over 50 % of people with ichthyosis vulgaris suffer from some type of atopic disease such as allergies, eczema, or asthma.
3.
Nor is there evidence that hygiene measures such as hand washing, food hygiene etc . are linked to increased susceptibility to atopic disease.
4.
There is substantial evidence in animal and some human studies that TGF-? in breast milk may be a key immunoregulatory factor in the development of infant immune response, moderating the risk of atopic disease or autoimmunity.
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